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News
KAIST cracks the code of RNA delivery in brain cells, opening new path for neurological treatment
14+ hour, 43+ min ago (490+ words) - Chemical tag m6A acts as a 'delivery label,' guiding RNA to the far ends of neurons - Study reveals new transport function of YTHDF2, previously known only as an RNA-degrading protein - Findings expected to shed light on RNA delivery errors behind neurodevelopmental and…...
New computational tool reads hidden RNA cleavage signals in health and
1+ day, 11+ hour ago (747+ words) For years, biologists catalogued small non-coding RNAs by counting how many of each type appeared in a sequencing run. That approach treated tiny RNA molecules as a census problem, and it worked well enough for microRNAs, the classical regulators of…...
Smart nanoparticles reprogram tumor immune cells to boost cancer attack
2+ day, 2+ hour ago (48+ words) Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune environment and strengthening anti-cancer T-cell activity in mice. Smart nanoparticles reprogram tumor immune cells to boost cancer attack Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune…...
RNA Profiling Splits Deadly Dog Spleen Cancer into Three Actionable
1+ day, 17+ hour ago (88+ words) One of the most lethal cancers in dogs has long frustrated veterinary oncologists with its stubborn one-size-fits-all treatment approach. Now, a research team at the University of São Paulo has shown that canine splenic hemangiosarcoma—a rapidly progressive cancer of…...
Cryo-EM Reveals the Dynamic Machinery That Switches Genes On
1+ day, 18+ hour ago (83+ words) Every cell in the human body carries the same genome, yet a neuron, a hepatocyte, and an immune cell behave in utterly different ways. The difference lies in which genes are switched on, when, and where. That act of switching,…...
Targeted nanoparticles strengthen anti-cancer immune responses in tumors
2+ day, 14+ hour ago (165+ words) Adelaide University researchers have developed a new way of using mRNA technology to reprogram tumor-supporting immune cells and strengthen the body's anti-cancer immune response. Targeted nanoparticles strengthen anti-cancer immune responses in tumors Adelaide University researchers have developed a new way…...
Smart Nanoparticles Reprogram Tumour Defenses to Boost Immune Attack on
2+ day, 11+ hour ago (814+ words) Scientists at Adelaide University have unveiled a new mRNA-based strategy that could reshape one of the most stubborn obstacles in cancer treatment: the hostile environment that tumours build around themselves to keep the immune system at bay....
GC Biopharma wins phase 2 nod for COVID-19 mRNA shot, targets Korea production by 2028
3+ day, 8+ hour ago (244+ words) Phase 2 to test dosing and immune response in adults as company eyes homegrown mRNA capacity by 2028 GCBiopharma will enter phase 2 of a coronavirus messenger ribonucleic acid (mRNA) vaccine candidate it is developing in-house. It plans to begin dosing the first…...
ARCT: Key clinical milestones for liver and lung mRNA therapies expected in the next 6–12 months
3+ day, 22+ hour ago (79+ words) TradingView Upcoming data readouts for liver (OTC deficiency) and lung (cystic fibrosis) mRNA programs are expected to shape the next year, with regulatory clarity and potential phase III advancement. The self-amplifying mRNA platform continues to generate revenue and attract interest…...
Interrogating RNA processing in cancer, splice by splice
4+ day, 4+ hour ago (18+ words) In this interview, we hear from Paul Boutz about how he is investigating RNA processing in cancer development....